The Revolutionary Drug Delivery Liposome

By Gabrielle Lambert


Liposome is designed to deliver drugs very effectively. It is made as an artificial cell, and it is useful in medicine in many different ways. There are three basic types of liposomes; MLV means multilamillar vesicle, and SUV and LUV are unilamellar vesicles, small and large ones. They have very specific spherical shape and high drug delivery efficacy. They can be designed for oral use, or in form of lotions, creams or patches. You can also inhale them in form of dry spray or nasal spray, or take them intravenously.

Medicine is not the only area where they can be used, although it might be considered as the most important one. Liposomes can be very useful in food industry, agriculture and, especially, cosmetology. They are build from natural substances, just like the real cell is, protect their contents and carry them safely to targeted destinations. High biocompatibility makes them an ideal carrier for different substances, and they improve the diffusion without causing unwanted side effects.

A liposome is actually very small bubble made of phospholipids, just like a cell membrane is built. They have a natural ability to target the exact area where needed, for example cancer. They can find and enter tumor sites, and release their content when in there. Tumor cells have different level of seals between cells, and liposomes can penetrate through their membranes.

In addition, they are capable to carry large pieces of DNA as well. In other forms of transfer, DNA gets damaged through various degrading processes, but this way it is protected from them. Capsules may have bi layered membranes, and they can carry positively, but also negatively charged molecules. Additionally, they can be both hydrophilic and lipophilic, or to have only one of those characteristics.

Some drugs would be more effective if carried to targeted area this way. Traditional oral capsules and pills can have problems with gastric system, and acid might destroy them partially. There are also different issues with hydrolysis and solubility. Using this type of drug carriers will significantly improve the effectiveness of different drugs and prolong the circulation time.

Recently, liposomes became very interesting for the specific oral delivery of different nutritional supplements. The majority of dietary and nutritional supplements in form of pills and capsules have very low level of absorption. Furthermore, traditional oral tablets are partially destroyed by the gastric system, losing their effectiveness.

Dietary and nutritional supplements can be carried within these small capsules to all targeting areas. Both lipophilic and hydrophilic nutritive supplements are effectively protected within those bubbles, and gastric system cannot harm them. Capsules ensure very high level of drug absorbtion, making those nutrients much more effective.

Nano liposome is extremely small, able to penetrate targeting areas quickly and even more efficiently. Results are promising, but only for high quality products. Many factors are involved here. The technology used in the process, the quality of raw phospholipids used for production, choosing the right size foe each purpose and other elements can affect the final absorption and efficacy. All in all, liposomes will probably change the pharmaceutical industry.




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