Everyday scientists and medical doctors work together to discover possible treatments, more likely a better one, for various medical diseases. Up until now, several medical conditions remain incurable such as AIDS and Cancer. But with continuous medical study and experimentation, some experiments have shown promising results, for an instance in autoimmune diseases such as that with liposomal clodronate.
True enough, the results on the several studies for such therapy were very promising, offering a new hope for patient suffering from immune system abnormalities. Liposome clodronate differs from any kind of therapy as it is delivered intracellularly. With the use of several advancements in medical therapy, treatment of medical diseases have become quite sophisticated indeed.
There are countless of cells that make up the immune system, macrophages however is said be the core of it. Its primary function is to activate natural immunity and regulate non-phagocytic cells. Macrophages play an important role in natural immune response and immunity, and are responsible in maintaining homeostasis by ingesting and digesting microorganism.
Clodronic acids is a first generation biphosphonate was originally used for the prevention and treatment of osteoporosis and reduce the risk of hyperparathyroidism, vertebral fractures, fracture related pain and hypercalcemia. It was during this time that the drug was discovered to have an effect in the immune system by reducing certain inflammatory markers.
As a whole, the immune system is a major factor in one's health and body. It does protect one on being infected from common viruses which explains why some people take supplementation to strengthen their immune system. But for some unique reason, the immune system could be the culprit to several medical diseases as well as on transplant rejections.
Autoimmune diseases are medical conditions caused by the immune system itself. Macrophages, the core cell of the immune system, attack healthy cells causing inflammation such as those in multiple sclerosis, pernicious anemia, rheumatoid arthritis and so on. During transplant, macrophages may also attack the new cells coming from the graft causing the body to reject it.
Using the liposomes as a drug vehicle, clodronic acid will be delivered into your phagocytic cell, or macrophages damaging it irreversibly then kills it eventually through apoptosis. Aptly name as the macrophage "suicide'', this will result to a decreased or minimal immune reaction hence patients with autoimmune disease may show improvement from their condition.
With the discovery of these new therapy, it surely increases the hope of anyone suffering from severe autoimmune diseases to achieve disease remission. This may also decrease the chances of transplant rejection to those patients scheduled for transplantation in any parts of the body. All in all, clodronic acid liposome therapy is promising a good quality of life among patients.
Liposomal clodronate was also discovered to have therapeutic effects in conjunction with anti tumor drugs used in Cancer. Clodronic acid is said to improve the drug absorption of antineoplastic drugs as well as demonstrated the possibility of slowing down cancer growth however, this mode of action is yet to be proved. The combination of decreasing blood vessel density and tumor size shows great promise.
True enough, the results on the several studies for such therapy were very promising, offering a new hope for patient suffering from immune system abnormalities. Liposome clodronate differs from any kind of therapy as it is delivered intracellularly. With the use of several advancements in medical therapy, treatment of medical diseases have become quite sophisticated indeed.
There are countless of cells that make up the immune system, macrophages however is said be the core of it. Its primary function is to activate natural immunity and regulate non-phagocytic cells. Macrophages play an important role in natural immune response and immunity, and are responsible in maintaining homeostasis by ingesting and digesting microorganism.
Clodronic acids is a first generation biphosphonate was originally used for the prevention and treatment of osteoporosis and reduce the risk of hyperparathyroidism, vertebral fractures, fracture related pain and hypercalcemia. It was during this time that the drug was discovered to have an effect in the immune system by reducing certain inflammatory markers.
As a whole, the immune system is a major factor in one's health and body. It does protect one on being infected from common viruses which explains why some people take supplementation to strengthen their immune system. But for some unique reason, the immune system could be the culprit to several medical diseases as well as on transplant rejections.
Autoimmune diseases are medical conditions caused by the immune system itself. Macrophages, the core cell of the immune system, attack healthy cells causing inflammation such as those in multiple sclerosis, pernicious anemia, rheumatoid arthritis and so on. During transplant, macrophages may also attack the new cells coming from the graft causing the body to reject it.
Using the liposomes as a drug vehicle, clodronic acid will be delivered into your phagocytic cell, or macrophages damaging it irreversibly then kills it eventually through apoptosis. Aptly name as the macrophage "suicide'', this will result to a decreased or minimal immune reaction hence patients with autoimmune disease may show improvement from their condition.
With the discovery of these new therapy, it surely increases the hope of anyone suffering from severe autoimmune diseases to achieve disease remission. This may also decrease the chances of transplant rejection to those patients scheduled for transplantation in any parts of the body. All in all, clodronic acid liposome therapy is promising a good quality of life among patients.
Liposomal clodronate was also discovered to have therapeutic effects in conjunction with anti tumor drugs used in Cancer. Clodronic acid is said to improve the drug absorption of antineoplastic drugs as well as demonstrated the possibility of slowing down cancer growth however, this mode of action is yet to be proved. The combination of decreasing blood vessel density and tumor size shows great promise.
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